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deCODE genetics

2024-10-29 18:00 1,130

?????, ?????, 2024? 10? 29? /PRNewswire/ -- ??? ????/??(deCODE genetics/Amgen) ????? ??? ????? ? ?? ??? ??? ?? ?? ?? ??? ?? ??? ??? 6?? ????. ? ?? ??? ?? ??? ????? "?? ?? ?? ??? ??? ?? ?? ???? ?? 6?? ? ??? ???"?? ???? ?????.

Kari Stefansson senior author of the paper, “Gene-based burden tests of rare germline variants identify six cancer susceptibility genes”, published today in Nature Genetics, discusses the paper with Erna V. Ivarsdottir first author on the paper.

?? ?? ? ?? ??? ?? ????? ??? ?? ??? ??? ??? ????? ????. BRCA1 ? BRCA2 ?? ??? ?? ??? ??? ????? ?? ?? ??? ?? ???? ??? ??? ????? ??? ????? ?? ???? ? ??? ??? ??? ????.

? ???? ????? 130,991?? ? ??? 733,486?? ???? ??? ??? ???? ??? ??? ??? ?? 3?? ????. ??? 22? ? ??? ?? ??? ?? ?? ??? ??? ?? ? ?? ??? ??? 4?? ??? ???? ?????, ???? ????? ????? ?? ??? BIK, ???? ????? ??? ATG12, ????? TG, ??? ?? ??? ? ??? CMTR2 ? 4???. ??? ??? ?? ???? ? ?? ??? ??? ???? ?????(90~295%), ?? ?? ?? ? ???? ?? ? ?? ??? ???? ??? ? ??? ?? ???? ??.

?? ???? ? ?? ?? ??? ??? ?? ??? ?? ??? ????? ????. ?????, AURKB ??? ?? ? ??? ?? ?? ??? ????, PPP1R15A ??? ??? ?? ??? 53% ??? ?? ??? ???. ??? ??? PPP1R15A ??? ??? ??? ? ?? ??? ? ? ??? ????.

?? ??? ? ?? ? ??? ?? ???? ??? ? ?? ??? ???? ? ?? ??? ??? ???? ????? ?? ??? ??? ????.

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Kari Stefansson CEO of deCODE genetics and senior author on the paper in Nature Genetics, with Erna V. Ivarsdottir scientists at deCODE genetics and first author.

??: deCODE genetics

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